The $800 Million Gamble: Jumping Aboard or Jumping the Gun? (14 Mar 2012)

Richard A. Lange, MD, MBA and L. David Hillis, MD

In the CLOSURE I trial (Evaluation of the STARFlex Septal Closure System in Patients with a Stroke and/or Transient Ischemic Attack Due to a Presumed Paradoxical Embolism through a Patent Foramen Ovale), 909 patients with a PFO who had a stroke or a transient ischemic attack (TIA) of unclear etiology were randomly assigned to device…

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