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Intense Exercise Doesn’t Eliminate the Hazard of Intense Sitting (19 Jan 2015)

A large new analysis published in Annals of Internal Medicine supports earlier observations that the health hazards of sedentary behavior aren’t completely neutralized by exercise. Researchers in Toronto scoured the literature to find studies that assessed the health effects of sedentary behavior adjusted for physical activity. They found 47 studies, including 13 that assessed all-cause mortality, 14…

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Optimum Salt Intake in Elderly Remains Elusive (19 Jan 2015)

A new study offers fresh evidence that current salt recommendations should be taken with, well, a grain of salt. Current guidelines now recommend that everyone should have sodium intake levels below 2300 mg per day. For many people at higher risk, including everyone over 50 years of age, sodium intake should be below 1500 mg/d….

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Hidden Clinical Trial Data: A Dam About to Burst (14 Jan 2015)

Two important new developments may mean that many more researchers will soon be able to access and analyze data from many more clinical trials. In recent years, in response to troubling and far-reaching questions about the availability and reliability of clinical trial data, reformers have called for new policies that would require drug companies and…

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Ticagrelor Improves Outcomes After Myocardial Infarction (14 Jan 2015)

For the first time, a very large trial has shown that dual antiplatelet therapy (DAPT) improves cardiovascular outcomes when given to patients 1 to 3 years after a myocardial infarction. Because DAPT has been shown previously to reduce the high risk of recurrent events for up to a year following an MI, it is considered to be standard…

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40-Year Effort in One Rural County to Prevent Cardiovascular Disease Found Successful (13 Jan 2015)

A 40-year program in one poor rural county to combat cardiovascular disease appears to have been successful, resulting in reduced rates of hospitalization and death compared with other counties in the same state over the same period. The new findings are described in a paper published in the Journal of the American Medical Association. Beginning in 1970, Franklin…

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High Rate of Inappropriate Use of Aspirin for Primary Prevention (12 Jan 2015)

More than a third of U.S. adults — more than 50 million people — now take aspirin for the primary and secondary prevention of cardiovascular disease. Although it was once broadly recommended, aspirin for the primary prevention of cardiovascular disease is now only indicated in people who have a moderate-to-high 10-year risk. Now a new report published in…

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FDA Approves New Oral Anticoagulant from Daiichi Sankyo (9 Jan 2015)

And then there were four. Late Thursday the FDA announced that it had approved edoxaban, the new oral anticoagulant manufactured by Daiichi Sankyo. The drug will be marketed under the brand name of Savaysa and joins three other new drugs in the large and important new oral anticoagulant marketplace: dabigatran (Pradaxa), rivaroxaban (Xarelto), and apixaban (Eliquis). All four drugs…

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FDA Approves New Drug-Coated Balloon to Open Blocked Leg Arteries (5 Jan 2015)

Medtronic said today that it had received approval from the FDA to market its IN.PACT Admiral drug-coated balloon (DCB) to treat peripheral artery disease (PAD) in the superficial femoral and popliteal arteries. The device is the second DCB to gain FDA approval. Last October the FDA approved CR Bard’s Lutonix DCB for a similar indication. The new DCB uses the anti-proliferative drug…

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Healthy Habits of Young Women Lead to Long-Term Health Benefits (5 Jan 2015)

It may seem obvious, but a new study shows that young women with healthy habits are less likely as they age to get coronary heart disease or go on to develop cardiovascular risk factors like high blood pressure, high cholesterol, or diabetes. Andrea Chomistek and colleagues analyzed data from more than 88,000 women participating in…

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Dutch Trial Gives Support to Thrombectomy for Ischemic Stroke (17 Dec 2014)

A large new trial provides the first substantial evidence that thrombectomy may be beneficial in patients with acute ischemic stroke. Previous thromboectomy trials have been disappointing; some experts have speculated this may be due to the use of early-generation devices, long treatment delays, and difficulties in recruiting suitable patients into the trials. The Multicenter Randomized…

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