“Doc, I Got My Whole Genome Scanned – Now What?” (19 Sep 2011)
Susan Cheng, MDWhat do you do if your patient shows you a commercially produced report of a personal whole genome scan?
Coronary and Cerebrovascular Disease May Differ in Their Heritability (26 Jul 2011)
Although coronary and cerebrovascular disease usually receive equal weight when family history is assessed as a risk factor, a new study suggests that family history may play a more important role in MI and ACS than in stroke or TIA. In an article published in Circulation: Cardiovascular Genetics, Amitava Banerjee and colleagues report the results…
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Genome Studies Pool Data to Gain Power (7 Oct 2010)
Leaders of several genome-wide association studies have agreed to collaborate and combine their data in the hope that by dramatically raising the sample size of their studies, they will “contribute to our understanding of the role of common genetic variation on risk for CAD and MI.” In an article in Circulation: Cardiovascular Genetics, Michael Preuss and…
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The CURE for Clopidogrel Genotyping? (31 Aug 2010)
Guillaume Pare, MD, MScCardioExchange welcomes Guillaume Paré to discuss his team’s work on the utility of clopidogrel genotyping. The researchers genotyped for CYP2C19 alleles associated with loss-of-function or gain-of-function of clopidogrel in some 5,000 patients with ACS or A-fib from two large randomized trials. In both studies, clopidogrel had similar efficacy over placebo regardless of whether patients had…
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Genetic Substudies of Large Trials Question Value of Clopidogrel Genotyping (29 Aug 2010)
Genetic substudies across a broad range of large clinical trials that used clopidogrel raise questions about the clinical utility of clopidogrel genotyping. The substudies come from large and important trials like PLATO, TRITON-TIMI 38, CURE, and ACTIVE A. A genetic substudy of PLATO finds that ticagrelor is superior to clopidogrel irrespective of genetic subtype. Therefore,…
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What Do Cardiologists Need to Know About 9p21? (11 Aug 2010)
Jeffrey Lance Anderson, MDCardioExchange welcomes Jeffrey Anderson to discuss his recent editorial in the Journal of the American College of Cardiology on the 9p21 locus and CHD. Dr. Anderson and co-author Benjamin Horne carefully evaluated the relationship of 9p21 to CHD and conclude that 9p21 appears to be an initiator of and may be a promoter of CHD,…
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