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Selections from Richard Lehman’s Literature Review: March 23rd (23 Mar 2015)

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Richard Lehman, BM, BCh, MRCGP

This week’s topics include antiplatelet therapy duration following bare metal or drug-eluting coronary stents, thrombolysis in acute ischemic stroke, and more.

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A Close Examination of Recent Studies of Endovascular Treatment for Acute Ischemic Stroke (19 Feb 2015)

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Rory J Spiegel, MD

Rory Spiegel takes a close look at the MR CLEAN, EXTEND-IA, and ESCAPE trials.

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Three Trials Show Benefits of Thrombectomy in Stroke Patients (12 Feb 2015)

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Three new studies offer important additional evidence that early treatment with current thrombectomy devices that extract clots from blood vessels in the brain can lead to improved outcomes in carefully selected stroke patients. The trials were stopped early based on efficacy following positive findings last year from another trial, MR CLEAN. The three new trials…

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Selections from Richard Lehman’s Literature Review: August 11th (11 Aug 2014)

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Richard Lehman, BM, BCh, MRCGP

This week’s topics include the effects of intensive glucose control on ischemic heart disease and a meta-analysis of the effects of thrombolysis with alteplase for acute ischemic stroke.

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Large Analysis Supports Thrombolysis for Stroke (5 Aug 2014)

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Although thrombolysis for ischemic stroke has been widely recognized as beneficial, its use has been limited because of concerns about its effects in patients treated after 3 hours, in older patients, and in patients with mild and with severe strokes. Now a meta-analysis published in the Lancet offers evidence that the use of thrombolysis should be…

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Selections from Richard Lehman’s Literature Review: June 23rd (23 Jun 2014)

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Richard Lehman, BM, BCh, MRCGP

This week’s topics include thrombolysis for pulmonary embolism, the effect of screening and lifestyle counseling on the incidence of ischemic heart disease in the general population, and more.

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A Meta-Look at Thrombolysis vs. Conventional Anticoagulation for PE (17 Jun 2014)

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Jay Giri, MD, MPH and Saurav Chatterjee, MD

Jay Giri and Saurav Chatterjee discuss their meta-analysis of trials comparing thrombolytic therapy and conventional anticoagulation in patients at intermediate risk for pulmonary embolism.

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Mixed Results for Thrombolysis in Pulmonary Embolism (17 Jun 2014)

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  The role of thrombolytic therapy for the treatment of pulmonary embolism has been unclear, as it has been difficult to measure the precise balance between enhanced clot-dissolving efficacy and greater bleeding risk produced by thrombolysis when compared with conventional anticoagulation. A new meta-analysis published in JAMA analyzed data from 16 randomized trials including 2115 patients….

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Selections from Richard Lehman’s Literature Review: April 28th (28 Apr 2014)

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Richard Lehman, BM, BCh, MRCGP

This week’s topics include BP targets during septic shock, reducing time-to-needle times in acute ischemic stroke, and an increase in fat and calorie consumption in U.S. statin users.

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Selections from Richard Lehman’s Literature Review: August 19th (19 Aug 2013)

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Richard Lehman, BM, BCh, MRCGP

This week’s topics include treating to risk, not to target; perceived job insecurity as a risk factor for incident CHD; ischemic preconditioning in patients undergoing CABG, and more.