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Selections from Richard Lehman’s Literature Review: February 2nd (2 Feb 2015)

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Richard Lehman, BM, BCh, MRCGP

This week’s topics include less-tight vs. tight hypertension control in pregnancy, icatibant for ACE-inhibitor-induced angioedema, and more.

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Tight Control of Hypertension During Pregnancy Tested (28 Jan 2015)

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High blood pressure during pregnancy is increasingly common, largely due to older age and obesity. Although there is widespread agreement that hypertension in these women should be treated when it is high enough to raise the risk of stroke, there is little agreement about whether or how to treat mild hypertension. In a study reported…

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Can Precision Medicine Do Better Than Precision Weather? (27 Jan 2015)

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Larry Husten, PhD

Larry Husten asks the question, “Is the human body simpler than the weather?”

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Califf to Leave Duke to Become FDA Deputy Commissioner (26 Jan 2015)

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The FDA announced today that Duke University cardiologist Robert Califf will be the next FDA Deputy Commissioner for Medical Products and Tobacco. The agency said that Califf will be responsible for the Center for Drug Evaluation and Research, the Center for Biologics Evaluation and Research, the Center for Devices and Radiological Health and the Center for Tobacco…

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Selections from Richard Lehman’s Literature Review: January 26th (26 Jan 2015)

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Richard Lehman, BM, BCh, MRCGP

This week’s topics include dietary sodium content, mortality, and CVD risk in older adults, the ROX CONTROL HTN study, and more.

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New Device to Lower Resistant Hypertension Shows Early Promise (22 Jan 2015)

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A novel implantable device appears to show early promise in the treatment of resistant hypertension. The “Coupler” device from ROX Medical is about the size of a paper clip and is delivered via a catheter to the upper thigh, where it creates an anastomosis between the distal external iliac vein and artery, thereby mechanically lowering…

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A Tragic Loss (21 Jan 2015)

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Harlan M. Krumholz, MD, SM

The news of the death of Michael Davidson, a surgeon at Brigham and Women’s Hospital, allegedly at the hands of a patient’s relative, has shaken us all. The words of Betsy Nabel, on behalf of BWH, conveyed how much he was respected and loved. To his family, friends and colleagues, we send our sympathy. As…

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Intense Exercise Doesn’t Eliminate the Hazard of Intense Sitting (19 Jan 2015)

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A large new analysis published in Annals of Internal Medicine supports earlier observations that the health hazards of sedentary behavior aren’t completely neutralized by exercise. Researchers in Toronto scoured the literature to find studies that assessed the health effects of sedentary behavior adjusted for physical activity. They found 47 studies, including 13 that assessed all-cause mortality, 14…

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Putting Your Heart Into Your Music: Beethoven’s Cardiac Arrhythmia (19 Jan 2015)

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Zachary Goldberger, MD, MS

Zachary Goldberger discusses his collaborative study of the relationship between cardiac health and musical composition inspired by the work of Ludwig van Beethoven.

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Optimum Salt Intake in Elderly Remains Elusive (19 Jan 2015)

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A new study offers fresh evidence that current salt recommendations should be taken with, well, a grain of salt. Current guidelines now recommend that everyone should have sodium intake levels below 2300 mg per day. For many people at higher risk, including everyone over 50 years of age, sodium intake should be below 1500 mg/d….

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