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FDA Grants Apixaban Expanded Indication for Venous Thromboembolism (21 Aug 2014)

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The FDA today approved an expanded indication for the oral anticoagulant apixaban (Eliquis, Bristol-Myers Squibb and Pfizer). Apixaban will now be indicated for the treatment of deep venous thrombosis (DVT) and pulmonary embolism (PE), and for the reduction in the risk of recurrent DVT and PE (collectively known as venous thromboembolism) after initial therapy. The supplemental new…

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Avatar of Harlan M. Krumholz, MD, SM

The Niacin Controversy: What Do You Say to Your Patient? (21 Aug 2014)

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Harlan M. Krumholz, MD, SM

In this scenario based on the HPS2-THRIVE study, Harlan Krumholz asks, “What do you say to your patient?”

Avatar of Larry Husten, PHD

Increased Cardiac Risk Linked to Clarithromycin (19 Aug 2014)

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Acute use of the popular macrolide antibiotic clarithromycin has been linked to a small but significant increase in cardiac death. In a report in the BMJ, researchers in Denmark analyzed the effects over a 14-year period of the acute use of penicillin V, roxithromycin, and clarithromycin. Earlier research raised concerns that marcrolide antibiotics in general, and erythromycin and azithromycin…

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Selections from Richard Lehman’s Literature Review: August 18th (18 Aug 2014)

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Richard Lehman, BM, BCh, MRCGP

This week’s topics include the three sodium studies from NEJM, the CLARIFY study, and more.

Avatar of Larry Husten, PHD

An Expert’s Perspective: Why Salt Is Not Like Tobacco and Why Guidelines Are Tricky (18 Aug 2014)

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At the center of this week’s renewed debate on salt was Salim Yusuf, the longtime influential and occasionally controversial cardiology researcher and clinical trialist based at McMaster University in Hamilton, Ontario. I spoke with Yusuf before the publication of the New England Journal of Medicine papers, which include his own two papers from the PURE study. Yusuf was troubled…

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Avatar of Larry Husten, PHD

New Analysis of Old Study Fuels Debate Over Blood Pressure Guidelines (18 Aug 2014)

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In the last year new guidelines relating to cardiovascular disease have been the subject of intense criticism and debate. The status of the blood pressure guidelines has been particularly contentious, since several different groups have published contradictory guidelines, while several authors of the most prominent group, the Eighth Joint National Committee, published an impassioned dissent…

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Disparities in Healthcare: Young Women Continue to Fare Worse than Men after an AMI (18 Aug 2014)

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Aakriti Gupta, MD

Dr. Aakriti Gupta confronts the necessity to continue to spread awareness of the risk of AMI to young women in her analysis of the findings from her recent study on the subject.

Avatar of Larry Husten, PHD

Two New Studies Fuel the Debate Over Sodium (13 Aug 2014)

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Three papers and an editorial in the New England Journal of Medicine are sure to throw fresh fuel on the ongoing fiery debate over sodium recommendations. Current guidelines recommend that people should limit their intake of sodium to 1.5  to 2.4 grams per day, but these recommendations are based on projections and have never been tested in…

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With Health Disparities Research, Descriptive Analysis Isn’t Enough (13 Aug 2014)

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Paul S. Chan, MD, MS

Paul Chan takes a critical look at the shortcomings of the current state of disparities research and asks what we could do differently to improve the lives of others.

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From the Mouths of Babes (12 Aug 2014)

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Westby G Fisher, MD

Wes Fisher reflects on how his “Bring Your Daughter to Work” days, both then and now, caused him to value his experience as a physician.