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Avatar of Benjamin Scirica, MD MPH

New Observations on Saxagliptin (15 Sep 2014)


Benjamin Scirica, MD MPH

Benjamin Scirica discusses his study group’s new analysis of data from the SAVOR-TIMI 53 randomized, placebo-controlled trial of saxagliptin in patients with type 2 diabetes.

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Race and Ethnicity Do Not Affect the Benefits of Device Therapy in Heart Failure (11 Sep 2014)


Boback Ziaeian, MD

Boback Ziaeian discusses his observational study exploring the benefits of guideline-recommended cardiac resynchronization therapy and ICD therapy in heart failure patients, according to race and ethnicity.

Avatar of CardioExchange Editors, Staff

Perspectives on PARADIGM-HF (5 Sep 2014)


CardioExchange Editors, Staff

The Editors present a distillation of reader comments on a popular post.

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Let’s Take a Close Look at PARADIGM-HF (1 Sep 2014)


Vinay Prasad, MD MPH

Vinay Prasad explores three reasons why clinicians should have reservations about the findings from PARADIGM-HF.

Avatar of Larry Husten, PHD

SIGNIFY Trial Provokes Sound and Fury Over Controversial Drug (31 Aug 2014)


The already controversial drug ivabradine just got a little more controversial. The drug, which is marketed by Servier under the brand names of Corlentor and Procoralan, is available in Europe and elsewhere and is used for the treatment of heart failure and stable angina. The drug is not available in the U.S., but it is under development by Amgen for a…

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Avatar of John McMurray, MbChB MD

Will There Be a PARADIGM Shift in Treatment of Heart Failure? (30 Aug 2014)


John McMurray, MbChB MD and Milton Packer, MD

John J.V. McMurray and Milton Packer, the two lead authors of the PARADIGM-HF trial, discuss the randomized comparison of angiotensin–neprilysin inhibition with the ACE inhibitor enalapril.

Avatar of Larry Husten, PHD

Predicting PARADIGM-HF, or What to Expect When You’re Expecting (28 Aug 2014)


Larry Husten, PhD

Larry Husten analyzes the expectations surrounding the upcoming release of PARADIGM-HF and its centerpiece LCZ696 from the perspective of the medical field as well as the world of economics.

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The CardioMEMS HF System: What Do You Say to Your Patient? (14 Aug 2014)


John Ryan, MD

In this scenario based on a patient’s question about the CardioMEMS device, John Ryan asks, “What do you say to your patient?”

Avatar of Larry Husten, PHD

Study Offers Little Support for an Old Drug (11 Aug 2014)


Digoxin is one of the oldest drugs in the cardiovascular arsenal, derived from the foxglove plant and first described in the 18th century by William Withering. It is frequently used in patients with heart failure (HF) and with atrial fibrillation (AF). The few trials supporting its use were performed in HF patients before newer treatments…

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Avatar of Ileana

Cardiac Rehab for Heart Failure Patients: The CMS Is Convinced — Are You? (29 Jul 2014)


Ileana Piña, MD, MPH and John Ryan, MD

John Ryan interviews Dr. Ileana Piña about her work in HF-ACTION as it relates to the CMS’s recent expansion of cardiac rehabilitation coverage.