There’s been a remarkable increase in the use of IVC filters, but what is the evidence base behind this mechanistically appealing approach?

In less than two weeks, on March 9, the main results of the HPS2-THRIVE (Heart Protection Study 2-Treatment of HDL to Reduce the Incidence of Vascular Events) study will be presented in San Francisco at the annual meeting of the American College of Cardiology. The results have been eagerly awaited since Merck’s brief announcement in December that the trial had not met its primary endpoint and that it…

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Giving an ACE inhibitor to people with peripheral artery disease (PAD) and intermittent claudication reduces pain and increases walking time, according to a new study published in JAMA. Currently the pharmacologic options for this patient population are few and have limited efficacy. Researchers at three Australian hospitals randomized 212 patients with PAD to receive the ACE inhibitor ramipril or placebo for…

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Prior to Hurricane Katrina, myocardial infarctions (MIs) in New Orleans followed a well-known circadian and septadian (today’s word of the day, meaning day of the week) pattern, with predictable increases on Mondays and in the morning hours. Now a new study from the American Journal of Cardiology finds that the notorious 2005 hurricane dramatically altered that pattern…

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Renal denervation for resistant hypertension is generating a lot of excitement. In this blog, Rick Lange and David Hillis take stock of the evidence and the efforts underway to explore the potential scope of indications for the procedure.

Four common cardiovascular risk factors — smoking, hypertension, hypercholesterolemia, and type 2 diabetes — appear to account for most of the risk for peripheral artery disease in middle-aged and older men.

Revatio (sildenafil) should not be prescribed to children and adolescents with pulmonary arterial hypertension, according to an FDA MedWatch alert. The warning is based on the results of a trial published in Circulation that showed increased mortality at medium and high doses of Revatio, compared with low-dose treatment, among patients aged 1 to 17 years….

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Although people with atrial fibrillation (AF) and people with chronic kidney disease (CKD) are at elevated risk for stroke and other vascular events, people with both conditions have not been well studied, since those with CKD have been excluded from most clinical trials of stroke prevention for AF. The problem is further compounded because the…

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A large study reports a high increased risk for acute MI (AMI) in the first 6 weeks after total-hip replacement (THR) or total-knee replacement (TKR) surgery. Analyzing a nationwide cohort from Denmark that included 95,227 patients who underwent THR or TKR and matched controls, Arief Lalmohamed and colleagues calculated the adjusted hazard ratios (HR) for AMI. Their…

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The coronary track this morning began with discussions of the rationale for CTO interventions in “the era of appropriate use criteria” and of how to recognize unfavorable features for CTO PCI. The session concluded with two live case transmissions. The first case was of a 55-year-old man, an exsmoker with a history of diabetes mellitus…

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