Composite Endpoints and the CREST Trial (4 Jun 2010)

David Rind, MD

CardioExchange welcomes this guest post reprinted with permission from Dr. David Rind, an academic primary care physician and medical editor in Boston. This piece originally appeared on his blog, Evidence in Medicine. For more on the CREST trial, see the NEJM article and editorial, the Journal Watch summary by Dr. Howard Herrmann, and an Interventional Cardiology blog by Dr. Richard Lange. In recent years, a common practice in clinical trials is to make the primary endpoint a composite endpoint. That is, the primary endpoint is a combination of various clinical events that might happen,… Continue Reading